A comprehensive resource on the recent developments of stem cell use in wound healing

With contributions from experts in the field,Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds.

Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource:

Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.

Kürsad Türksen is a Senior Scientist in Chronic Disease at the Ottawa Health Research Institute and an Asisstant Professor of Biochemistry at the University of Ottawa in Ottawa, ON, Canada.

List of Contributorsvii

1 Stem Cell Regeneration and Repair Overview 1
Clement D. Marshall, Alessandra A. Moore, Michael T. Longaker, and H. Peter Lorenz

2 Cadherins as Central Modulators of Wound Repair 15
Melissa Crawford and Lina Dagnino

3 Tight Junctions and Cutaneous Wound Healing 31
Thomas Volksdorf and Johanna M. Brandner

4 The Role of Microvesicles in Cutaneous Wound Healing 43
Alexandra Laberge and Véronique J. Moulin

5 Wound Healing and Microenvironment 67
Elgin Türköz Uluer, Hafize Seda Vatansever, and Feyzanzdal Kurt

6 Wound Healing and the Non-cellular Microenvironment 79
Hayley S. Ramshaw, Jasreen Kular, and Michael S. Samuel

7 Contribution of Adipose-Derived Cells to Skin Wound Healing 89
Barbara Gawronska-Kozak, Joanna Bukowska, Xiying Wu, Amy Lin Strong, Trivia Frazier, Bruce A. Bunnell, and Jeffrey M. Gimble

8 Role of Bone Marrow-Derived Stem Cells in Wound Healing 103
FeyzanÖzdal Kurt, Hafize Seda Vatansever, and Elgin Türköz Uluer

9 Role of Vitamin D and Calcium in Epidermal Wound Repair 113
Daniel D. Bikle, Chia-ling Tu, and Yuko Oda

10 Oral Mucosal Healing 125
Luisa A. DiPietro and Megan Schrementi

11 Role of Adipose-Derived Stem Cells in Wound Healing: An Update from Isolation to Transplantation 133
Selami Demirci, Ayegül Doan, and Fikrettinahin

12 The Hair Follicle as a Wound Healing Promoter and Its Application in Clinical Practice 149
Francisco Jimenez, María Luisa Martínez, Eduardo Escario, and Ander Izeta

13 Impaired Wound Healing in Diabetic Ulcers: Accelerated Healing Through Depletion of Ganglioside 167
Duncan Hieu M. Dam, Sophia A. Jelsma, and Amy S. Paller

14 Inflammation in Wound Repair: Role and Function of Inflammation in Wound Repair 177
Amanda S. MacLeod and Jeffery T. Kwock

15 Inflammation, Wound Healing, and Fibrosis 195
Shibnath Ghatak, Vincent C. Hascall, Ricardo Moreno Rodriguez, Roger R. Markwald, and Suniti Misra

16 The Potential Role of Photobiomodulation and Polysaccharide-Based Biomaterials in Wound Healing Applications 211
Heidi Abrahamse, Sathish Sundar Dhilip Kumar, and Nicolette Nadene Houreld

17 Is Understanding Fetal Wound Repair the Holy Grail to Preventing Scarring? 225
Olivier A. Branford and Kerstin J. Rolfe

18 Inflammation and Cancer 239
Suniti Misra, Vincent C. Hascall, Roger R. Markwald, Paul E. OBrien, and Shibnath Ghatak

Index 275