InhaltsangabeIntroduction. Part One: Coronary Heart Disease in Families and Populations. 1. Differences in frequency of atherosclerosis and coronary heart disease between populations and ethnic groups; U. Goldbourt. 2. Variation of atherosclerosis and coronary heart disease by age and sex; U. Goldbourt. 3. Familial clustering of coronary heart disease: a review of its significance and role as a risk factor for the disease: Y. Friedlander. 4. Studies of twins and adoptees in coronary heart disease; U. de Faire, N. Pedersen. Part Two: Coronary Heart Disease Risk Factors and Their Genetics. 5. Assessing genetic and cultural heritabilities; D.C. Rao, G.P. Vogler. 6. Lipids, apolipoproteins, and lipoproteins; D.J. Rader, H.B. Brewer Jr. 7. Low-density lipoprotein subclass phenotypes; M.A. Austin. 8. Rabbit models in genetic research in atherosclerosis; M. Shiomi, Y. Watanabe. 9. Fibrinogen, factor IVV, and plasminogen activator inhibitor-1; W.P. Fay, D. Ginsburg. 10. Homocysteine; K. Robinson, I.M. Graham. 11. Blood pressure variation; C.E. Grim, M.T. Robinson. 12. Rat models; Y. Yamori. 13. Human obesities; C. Bouchard. 14. Diabetes and insulin resistance; L.J. Raffel, T. Shohat, J.I. Rotter. 15. Smoking and sports participation; J.R. Koopmans, L.J.P. van Doornen, D.I. Boomsma. Part Three: Monogenic Traits Affecting Coronary Heart Disease Incidence. 16. Genetic defects in lipoprotein metabolism; G. Schonfeld, E.S. Krul. 17. Familial hypercholesterolemia; E. Leitersdorf. 18. Lp(a) lipoprotein: a monogenetic risk factor for cardiovascular disease; K. Berg. 19. Apolipoprotein E polymorphism and atherosclerosis risk; J. Dallongeville. Part Four: Molecular Approaches to Clinical Research. 20. From random genetic markers to candidate genes in association and linkage studies of coronary heart disease and its risk factors; K. Berg. 21. Plasma triglyceride transport; D.J. Galton, R.K. Mattu, J. Stocks. 22. Normal polymorphism at the low density lipoprotein receptor (LDLR) locus: effect on cholesterol levels and interaction with apolipoprotein E (apoE) genes; J.C. Pedersen, K. Berg. Part Five: Genetic Aspects of Vessel Wall Processes. 23. Intimal thickening, morphology and epidemiology; U. Goldbourt. 24. Regulation of arterial smooth muscle cell proliferation during development and lesion formation; J. Nilsson, A. Hultgårdh Nilsson. 25. Reverse cholesterol transport; J.M. Hoeg, A.T. Remaley. Part Six: Genetic Variation and Approaches to Clinical Research and Preventive/Public Health Actions. 26. Gene-environment interaction: variability gene concept; K. Berg. 27. Genetic factors, cardiovascular reactivity and blood pressure variability; T.G. Pickering, W. Gerin. 28. Genetic variation and nutrition; U. Goldbourt. 29. Genetic variation and cardiac pharmacotherapy; L. Arcavi. 30. Practical approaches for finding and helping coronary prone families with special reference to hypercholerolem